HIGHLIGHTS
- who: Nicolas Denans from the (UNIVERSITY) have published the research: An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish, in the Journal: (JOURNAL) of 24/Nov/2021
- what: Lastly, the authors show that IL-10 and IL-4 signaling act synergistically to promote synaptogenesis between hair cells and efferent neurons during regeneration. Altogether, this analysis shows a linear sequence of macrophage anti-inflammatory activation immediately after HC death starting with Glucocorticoid signaling, followed by IL-10 signaling, and lastly a combination of Polyamine and IL-4 signaling, which induces oxidative_phosphorylation . . .
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