Structural insight into the bulge-containing kras oncogene promoter g-quadruplex bound to berberine and coptisine

HIGHLIGHTS

• who: Kai-Bo Wang from the (UNIVERSITY) have published the paper: Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine, in the Journal: (JOURNAL) of 21/03/2022
• what: The authors report the NMR solution structures of a bulge-containing KRAS-G4 bound to berberine and coptisine, respectively. The authors focused on the KRAS1234, as G4 with shorter loop lengths is speculated to be thermodynamically and kinetically preferred51,52.
• how: The above data showed that berberine and coptisine strongly bind and stabilize the KRAS-G4 by . . .
  

   

  

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