HIGHLIGHTS
- who: DNA methylation et al. from the University, China have published the research work: Mechanisms of estrogen de ciency-induced osteoporosis based on transcriptome and DNA methylation, in the Journal: (JOURNAL)
- what: The authors constructed an Ovariectomized (OVX) model to mimic postmenopausal osteoporosis in human, and the model was monitored and evaluated using micro-CT, bone index evaluation, immunofluorescence staining, and pathology. In this study, the methylation map of the whole genome of two groups of mice was obtained using WGBS at the single-base level to demonstrate the influence of DNA methylation on osteoporosis . . .
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