Limiting glutamine utilization activates a gcn2/trail-r2/caspase-8 apoptotic pathway in glutamine-addicted tumor cells

HIGHLIGHTS

• who: Rosario Yerbes from the Cell culture HEK293, and , Bax/Bak KO. cell lines were kindly provided by Dr. A. Rodriguez (Universidad Autu00f3noma Madrid, Spain), Dr. J.A. Pintor-Toro (CABIMER, Seville, Spain) and Dr. C. Muu00f1oz-Pinedo (Idibell, Barcelona, Spain), respectively. MDA-, cells were a gift from Dr. J. Arribas (VallD`Hebron Institute of Oncology, Barcelona, Spain). MDA-, and , cells were maintained in DMEM medium supplemented with, % fetal bovine serum (Gibco), mM, glutamine, U of penicillin/ml and , u00b5g of streptomycin/ ml. , and , Bax/Bak K.O. cells, in McCoy`s medium supplemented with, % fetal bovine . . .
  

   

  

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