Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate

HIGHLIGHTS

• who: . and colleagues from the Gilead, United States Concordia University of Edmonton have published the research: Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate, in the Journal: (JOURNAL)
• what: For the first time, a rapid and sensitive LCu2012MS/MS bioanalysis method for quantification of glytrexate was developed and fully validated.
• how: 2.7.1 Experimental design of animal studies Pharmacokinetic and bioavailability studies were carried out in twenty-four male Sprague-Dawley rats. The precision and accuracy test results are shown in Table 1. All results indicated that . . .
  

   

  

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