Mucosal administration of a live attenuated recombinant covid-19 vaccine protects nonhuman primates from sars-cov-2

HIGHLIGHTS

• who: Mariana F. Tioni from the Male and female, h, Tg (strain #034860, B Cg-Tg[K18-ACE2] Prlmn/J) mice were procured from The Jackson Laboratory (Bar Harbor, ME) and were ~8, weeks old at the time of vaccination. The vaccine dose in mice was, ., u00d7 , PFU and the control group was immunized with , u03bcg of spike-alum. The animal studies were conducted in compliance with all relevant local, state, and federal regulations and were approved by the BIOQUAL Institutional Animal Care and Use Committee (IACUC). RSV Memphis37b was kindly provided by hVIVO (United Kingdom) and . . .
  

   

  

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