Car-tropic extracellular vesicles carry tumor-associated antigens and modulate car t cell functionality

HIGHLIGHTS

• who: V. M. Ukrainskaya from the Russian Academy of State University have published the paper: CAR-tropic extracellular vesicles carry tumor-associated antigens and modulate CAR T cell functionality, in the Journal: Scientific Reports Scientific Reports
• what: The authors have investigated whether binding of EVs, bearing B-cell surface antigen CD19, to CAR could be one of the main reasons of CAR T_cell dysfunction. The authors demonstrate via RNA-seq profiling that this idle activation contributes to the chronic stimulation, upregulates a set of genes (CTLA-4, LAG3, TIM3 and PDCD1LG2), participating in functional maturation . . .
  

   

  

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