Α-synuclein fibril-specific nanobody reduces prion-like α-synuclein spreading in mice

HIGHLIGHTS

• who: Yemima R. Butler from the University of Michigan, Ann Arbor, MI, USA have published the research: u03b1-Synuclein fibril-specific nanobody reduces prion-like u03b1-synuclein spreading in mice, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 31/05/2021
• what: The authors designed extracellular disulfide bond-free synthetic nanobody libraries by mutagenesis of the two conserved cysteine residues. The authors believe this work provides a proof-of-concept that targets intracellular u03b1-syn aggregates using AAV transduced u03b1-syn-fibril-specific nanobody can effectively reduce pathology propagation. The authors focus on using AAV . . .
  

   

  

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