Kw-2449 and vpa exert therapeutic effects on human neurons and cerebral organoids derived from mecp2-null hescs

HIGHLIGHTS

• who: Ya-Jie Xu from the (UNIVERSITY) have published the research work: KW-2449 and VPA exert therapeutic effects on human neurons and cerebral organoids derived from MECP2-null hESCs, in the Journal: (JOURNAL)
• what: This study provides new evidence showing that MECP2 depletion caused the deficits in dendritic morphology when the authors differentiated hESCs into 2D neurons and reduced cortical progenitor cells and neurons in 3D brain organoids. In consistent with previous findings that injection of KW-2449 ameliorates disease-associated respiratory and locomotion phenotypes in MeCP2 mutant mice , the authors provide important clues . . .
  

   

  

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