HIGHLIGHTS
- who: Peng Wang and colleagues from the Department of Medicine at Mount Sinai, New York, New York, USA have published the paper: Disrupting the DREAM complex enables proliferation of adult human pancreatic u03b2 cells Diabetes Obesity Metabolism, in the Journal: (JOURNAL) of June/10,/2022
- what: The authors demonstrate that small molecule DYRK1A inhibitors induce human u03b2 cells to replicate by converting the repressive DREAM complex to its pro-proliferative MMB conformation. The authors report that DREAM plays a central role in enforcing replicative quiescence in the adult human u03b2 cell. While the studies described . . .
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