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Received: 1 April 2022 Check for updates Sameera Vipat 1,3, Dipika Gupta 2,3, Sagun Jonchhe2,3, Hele Anderspuk1, Eli Rothenberg2 and amp; Tatiana N. Moiseeva 1 DNA_polymerase epsilon (PolE) in an enzyme essential for DNA replication. After priming by DNA_polymerase alpha (POLA), the initial DNA synthesis during CMG bypass is performed by DNA_polymerase delta (POLD), with DNA_polymerase epsilon (POLE) taking over the leading_strand synthesis after the initial bypass of polymerases past one another2,5. DNA_polymerase epsilon (POLE) is a major DNA_polymerase, responsible for synthesizing the leading_strand during DNA replication6. The authors used . . .
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