Cas9-induced large deletions and small indels are controlled in a convergent fashion

HIGHLIGHTS

• who: Michael Kosicki from the The Cambridge Institute University of have published the paper: Cas9-induced large deletions and small indels are controlled in a convergent fashion, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS

SUMMARY

A frequency spectrum of indels resulting from NHEJ or MMEJ repair in a population of cells, the "indel profile", is specific to local DNA sequence of the target and generally stable across tested cell lines2-4. To study this 2 issue, the authors have built a library of mouse NGS-validated embryonic stem_cells deficient for 32 DNA repair . . .

 



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