Inverse folding based pre-training for the reliable identification of intrinsic transcription terminators

HIGHLIGHTS

SUMMARY

    Since probing of RNA structure experimentally is laborious, computationally predicting secondary_structure from sequence often serves as starting point to investigate ncRNA secondary_structure. To no surprise, deep neural_networks have been employed successfully to predict RNA secondary_structure. An obvious problem is the limited amount of training data for specific families or motifs of secondary_structure. The idea is to obtain a deep learning model that has explicitly learned secondary_structure through inverse folding, whilst maintaining the unconstrained flexibility to learn unknown and implicit variances beyond secondary_structure subsequent to pre-training. To address this, the authors perform systematic in . . .

     

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