Pim3-ampk-hdac4/5 axis restricts muervl-marked 2-cell-like state in embryonic stem cells

HIGHLIGHTS

• who: Xin Zhao from the State Key LaboratoryNankai University, Tianjin, People`s Republic of China have published the research: PIM3-AMPK-HDAC4/5 axis restricts MuERVL-marked 2-cell-like state in embryonic stem cells, in the Journal: (JOURNAL) of October/11,/2022
• what: The authors focused on studying HDAC5 and HDAC4. The authors propose the following model that in the presence of PIM3, hypo-phosphorylated HDAC4/5 repress MuERVL. The study demonstrates that PIM3 represses MuERVL and 2C-like state via AMPK by impeding the phosphorylation and nuclear export of HDAC4/5.
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