HIGHLIGHTS
- who: Xunshan Ren et al. from the Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, China have published the Article: Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain, in the Journal: (JOURNAL)
- what: The authors focused on the CaN/ NFAT signaling axis, a major downstream pathway of calcium signaling, to elucidate the mechanism of Piezo1-induced apoptosis and anabolic/catabolic imbalance in chondrocytes . The authors demonstrated that Piezo1 was significantly up-regulated in the articular cartilage of OA patients and ACLT-induced OA rats. The authors focused on the . . .
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