HIGHLIGHTS
SUMMARY
Crosstalk between Neural Cells Regulates Cholesterol Homeostasis Cholesterol homeostasis involves biochemical reactions, leading to cholesterol formation and complexation with apolipoproteins as well as an intense crosstalk between neural cells, which show the different abilities of these cells in the synthesis and request of this compound. The presence of ApoE is fundamental for the neuronal uptake of cholesterol by receptor-mediated endocytosis as it behaves as a ligand of some members of the low-density lipoprotein receptor (LDLR) family (LDL receptor related protein 1 (LRP1) and LDLR). The ABCA1 protein is considered a key molecule . . .
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