Numerical modeling of the dissolution of drug nanocrystals and its application to industrial product development

HIGHLIGHTS

  • who: Bastian Bonhoeffer and collaborators from the (UNIVERSITY) have published the research work: Numerical modeling of the dissolution of drug nanocrystals and its application to industrial product development, in the Journal: (JOURNAL)
  • what: The aim of this study was to manufacture a wide range of nanocrystal particle sizes by wet media milling technology with identical drug compound and formulation composition, including sub-100 nm particle sizes using an industrially applicable process design. Modelling results for in_vitro dissolution Further in silico studies were conducted to investigate the dissolution behavior of drug nanocrystals during in_vitro dissolution testing . . .

     

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