Patient-derived ipscs reveal evidence of telomere instability and dna repair deficiency in coats plus syndrome

HIGHLIGHTS

• who: Noufissa Oudrhiri and collaborators from the Inserm UMR_S_1310, Villejuif, France have published the research work: Patient-Derived iPSCs Reveal Evidence of Telomere Instability and DNA Repair Deficiency in Coats Plus Syndrome, in the Journal: Genes 2022, 13, x FOR PEER REVIEW of /2022/
• what: The authors report the establishment of a patient-derived iPSC model of CP. The authors show that, in comparison with cells of healthy controls, CP-iPSCs and their derivative mesenchymal stem_cells (MSC) express higher levels of telomerase and harbor telomere dysfunction, altered nuclear architecture, and higher radiation sensitivity with activation . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.