HIGHLIGHTS
- who: Jiansheng Jiang from the (UNIVERSITY) have published the research: Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation, in the Journal: (JOURNAL) of 12/05/2022
- what: The authors report here new structural models of tapasin based on X-ray diffraction data: tapasin-B44:05 and also two complexes with the antibodies PaSta1 and PaSta2. The authors compare the various models based on superposition of the N-IgV domains to visualize the potential for movement of the IgC domain, which is displaced by as much as 14.7 u00c5 (for tapasin . . .
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