Cdk1-cyclin-b1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry

HIGHLIGHTS

• who: Nan-Peng Chen from the Department have published the research: CDK1-cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry, in the Journal: (JOURNAL) of 10/08/2021
• what: The authors showed that the CDK1- cyclin B1 complex binds and phosphorylates the integrin activators KIND1 and KIND2 which triggers their ubiquitination and degradation followed by the disassembly and remodelling of FAs that subsequently enables the change in cell morphology from flat to round.
• future: Whether additional pathways such as Rap1 GTPase-mediated inactivation of talin regulation of actomyosin or . . .
  

   

  

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