The construction of a hypoxia-based signature identified ca12 as a risk gene affecting uveal melanoma cell malignant phenotypes and immune checkpoint expression

HIGHLIGHTS

SUMMARY

The survival time and risk score gene_expression were presented in order of the risk scores. The risk survival table depicts the risk score gene_expression pattern and patient survival status ranged by their risk score. The risk gene_expressions under hypoxia and the role of CA12 in UM cell EMT process. The protein bands of the risk gene_expressions under normal and hypoxia conditions (A) and the quantification of the protein expression results in the box plot (B). The authors confirmed the upregulation of the risk gene under hypoxia and validated that knockdown of CA12 inhibited UM . . .

 



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