Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations

HIGHLIGHTS

• who: Takuya Kobayashi from the Graduate School The University have published the article: Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors determine high-resolution closed and open structures of recombinant mouse RyR2. To support the hypothesis of gating mechanism, the authors determine the structures of a loss-of-function mutant. The authors demonstrate two fundamental mechanisms for channel gating of RyR2.
• how: Similar results were obtained with other substitutions in S4167 E4198 and . . .
  

   

  

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