Probabilistic quotient’s work and pharmacokinetics’ contribution: countering size effect in metabolic time series measurements

HIGHLIGHTS

  • who: Mathias Gotsmy from the Department of Analytical of Vienna, Vienna, Austria have published the article: Probabilistic quotientu2019s work and pharmacokineticsu2019 contribution: countering size effect in metabolic time series measurements, in the Journal: (JOURNAL)
  • what: The authors show that MIX normalization successfully tackles key weaknesses of the individual strategies: it (i) reduces the risk of overfitting with PKM and_(ii) contrary to PQN it allows to compute sample volumes. The authors explore the performance of three different normalization methods on synthetic data. The authors show that MIX significantly outperforms its preceding normalization methods. The authors . . .

     

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