HIGHLIGHTS
SUMMARY
The effect of chitin itself on immune_responses in the lungs is still controversial. In an analysis by Ilmarinen et_al YKL-40 was significantly overexpressed in the "obesity-related asthma" and "smokers` asthma" clusters compared to the "atopic asthma" cluster. In recent clinical studies, the YKL-40 serum level in asthmatics was found to correlate with neutrophil count, serum IL6, and sputum IL-1β. In contrast, T2-inflammatory enrichment was found in a cluster with better asthma control, low serum YKL-40 levels, and high total IgE. Role of YKL-40 in differentiating between asthma . . .
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