HIGHLIGHTS
SUMMARY
This approach has been successfully used for two proteins: sperm whale apomyoglobin (PDB:1bzp) and bovine carbonic anhydrase II (PDB:1v9e) (further in the text, just: apomyoglobin and carbonic anhydrase) (Baryshnikova et_al, 2005b; Samatova et_al, 2010; Melnik et_al, 2014). There are also many complex experimental and theoretical methods for determining "important" amino_acids or structural regions of a certain protein (Melnik et_al, 2012; Rocklin et_al, 2017; Ahmed et_al, 2022). In the search for amino_acids that affect the protein folding rate, the φ-value analysis was invented (Matouschek and Fersht, 1991; Fersht and Sato, 2004; Salvatella et_al . . .
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