Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner

HIGHLIGHTS

  • who: Lili-Naz Hazrati from the New York University, United States have published the article: Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner, in the Journal: (JOURNAL)
  • what: Using various molecular techniques and single cell RNA sequencing (scRNAseq) the authors show that the DNA damage response and cellular senescence are early events following rmTBI, in both glial and neuronal cell types. Consistent with these previous findings, this study has used scRNAseq to show that neurons are indeed enriched for pathways involved in cellular senescence . . .

     

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