Trabectedin and lurbinectedin: mechanisms of action, clinical impact, and future perspectives in uterine and soft tissue sarcoma, ovarian carcinoma, and endometrial carcinoma

HIGHLIGHTS

  • who: Angiolo Gadducci from the Papa Giovanni XXIII Hospital, Italy University of Turin, Italy have published the research work: Trabectedin and lurbinectedin: Mechanisms of action, clinical impact, and future perspectives in uterine and soft tissue sarcoma, ovarian carcinoma, and endometrial carcinoma, in the Journal: (JOURNAL)
  • what: In the second randomized stage of the study, an objective response was noted in 17% of 30 patients treated with lurbinectedin versus 0% of the 29 treated with topotecan.
  • future: Agents targeting TAMs and the other components of TME such as trabectedin and lurbinectedin can offer interesting . . .

     

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