Enantioselective nickel-catalyzed dicarbofunctionalization of 3,3,3-trifluoropropene

HIGHLIGHTS

  • who: Yun-Ze Li from the (UNIVERSITY) have published the paper: Enantioselective nickel-catalyzed dicarbofunctionalization of 3,3,3-trifluoropropene, in the Journal: (JOURNAL) of 25/04/2022
  • what: The authors report a nickel catalyzed enantioselective dicarbofunctionalization of inexpensive industrial chemical 3,3,3-trifluoropropene (TFP) with readily available tertiary alkyl and aryl iodides. Encouraged by this result, a survey of chiral ligands was conducted (entries 2-8).
  • how: To gain mechanistic insight into the reaction the authors conducted several radical trapping experiments (Fig 4).

SUMMARY

    The authors report . . .

     

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