Discovery of novel tetrahydro-β-carboline containing aminopeptidase n inhibitors as cancer chemosensitizers

HIGHLIGHTS

  • who: Xiaoyan Xing from the Department of Pharmacology, School of Pharmacy, Weifang Medical University, Weifang, China, Department of Medicinal have published the research: Discovery of Novel Tetrahydro-u03b2-carboline Containing Aminopeptidase N Inhibitors as Cancer Chemosensitizers, in the Journal: (JOURNAL)
  • what: In the present study, the contribution of both fatty_acid and aromatic linkers was evaluated in the designed APN inhibitors.
  • how: The result showed that the mRNA expression levels of OCT-4 SOX-2 and Nanog in the TNBC stem_cell spheres significantly decreased in the combined treatment groups compared with the control and . . .

     

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