Gdf15 and ace2 stratify covid-19 patients according to severity while ace2 mutations increase infection susceptibility

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SUMMARY

    Disease severity has been associated with older age, male sex, and comorbidities such as hypertension, diabetes, obesity, cardiovascular disease, chronic obstructive pulmonary disease, and lung, liver, and kidney disease (Huang C et_al, 2020; Chen et_al, 2020; Sanyaolu et_al, 2020). Severe or fatal cases of COVID-19 usually present with increased levels of pro-inflammatory cytokines and chemokines, known as cytokine storm (de la Rica et_al, 2020), low albumin levels (de la Rica et_al, 2020), as well as decreased lymphocyte counts and platelets, elevated levels of C-Reactive Protein (CRP), procalcitonin, D-dimer, lactate dehydrogenase . . .

     

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