Increased type i interferon signaling and brain endothelial barrier dysfunction in an experimental model of alzheimer’s disease

HIGHLIGHTS

  • who: Arundhati Jana from the DivisionUniversity of have published the research work: Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimeru2019s disease, in the Journal: Scientific Reports Scientific Reports
  • what: This study characterizes the brain endothelial barrier permeability and transcriptome in an experimental model of Alzheimer`s Disease.

SUMMARY

    Increased blood-brain barrier leakiness in APP/PS1 mice. The authors investigated blood-brain barrier integrity and Aβ deposition in 6-month-old female APP/PS1 mice which demonstrated minimal Aβ plaque deposition, as well . . .

     

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