Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration

HIGHLIGHTS

  • who: Sounak Sahu from the National Cancer Institute have published the Article: Growth factor dependency in mammary organoids regulates ductal morphogenesis during organ regeneration, in the Journal: Scientific Reports Scientific Reports
  • what: The authors investigate the role of EGF and FGF signaling factors in mammary organoid maintenance and proliferation in_vitro and their impact on organ regeneration in_vivo (Fig 1a). The authors develop a suspension culture method with minimal Matrigel to generate 3D mammary organoids. The authors developed fluorescence-based imaging modalities to visualize organ regeneration by utilizing a brighter fluorescent reporter and robust tissue clearing . . .

     

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