Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-pd-1 delivery for post-surgery tumor recurrence treatment

HIGHLIGHTS

• who: Zhaoting Li from the School University of have published the research work: Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show a biocompatible alginate-based hydrogel encapsulating PLX-loaded nanoparticles (designated PLX-NP) and anti-PD-1-conjugated platelets (designated P-aPD-1) for post-surgery tumor recurrence treatment, to achieve local and sustained release of PLX and anti-PD-1 antibodies for depleting TAMs and re-activating infiltrated T_cells, respectively . . .
  

   

  

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