HIGHLIGHTS
SUMMARY
The transient receptor potential melastatin 8 (TRPM8) protein is an ion_channel mainly responsible for regulating Ca2+ permeabilization. The TRPM8 ion_channel may regulate these processes in cancer cells by the enhancement of Ca2+-based intracellular signaling. The use of transcriptomics is well-known in cancer biology and the recent application of deconvolution networks to transcriptomic data has allowed the extraction and analysis of immune gene_expression patterns. Interactions between tumor and immune cells have been investigated for immunotherapeutic strategies such as immune checkpoint arrest, the harnessing of T_cells, and vaccine development. For integrated analysis of TRPM8 . . .
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