Acetyl-coa-carboxylase 1-mediated de novo fatty acid synthesis sustains lgr5+ intestinal stem cell function

HIGHLIGHTS

• who: Shuting Li from the Institute Braunschweig, Germany have published the research work: Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors demonstrate that intestinal epitheliumrestricted deletion of ACC1 results in damaged crypt formation in the small intestine and the colon of mice. The authors show that disrupting de novo FAS affects organoid development by diminishing the accumulation of intracellular lipids and restricting the activation of the PPARu03b4/u03b2-catenin signaling pathway. Cpt1a inhibition did not prevent the . . .
  

   

  

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