HIGHLIGHTS
- who: TYPE and colleagues from the University of Massachusetts Amherst, United States have published the research work: High-throughput screening method for discovering CatSper inhibitors using membrane depolarization caused by external calcium chelation and uorescent cell barcoding, in the Journal: (JOURNAL)
- what: Using CatSper1 KO sperm, the authors demonstrate for the first time that the depolarization induced by EGTA addition is strongly CatSper dependent. The authors propose an alternative method to specifically evaluate CatSper opening. This approach has been used in previous reports from the group (Torres-Flores et_al, 2011; Ernesto et_al, 2015; Ritagliati et_al . . .
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