Mitochondrial fatty acid β -oxidation is important for normal osteoclast formation in growing female mice

HIGHLIGHTS

• who: CPT and collaborators from the Satt Lutech, France University of Melbourne, Australia have published the Article: Mitochondrial fatty acid u03b2 -oxidation is important for normal osteoclast formation in growing female mice, in the Journal: (JOURNAL)
• what: The authors report that long chain fatty_acid u03b2-oxidation increases during osteoclast differentiation in_vitro and that inhibiting this metabolic pathway greatly diminishes osteoclast formation. The authors examined the necessity for mitochondrial long chain fatty_acid u03b2-oxidation during osteoclast development by disrupting the expression of Cpt2 in the myeloidmacrophage lineage (Clausen et_al, 1999; Gonzalez-Hurtado et_al, 2017).
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