Construction of a novel cuproptosis-related gene signature for predicting prognosis and estimating tumor immune microenvironment status in papillary thyroid carcinoma

HIGHLIGHTS

SUMMARY

    The stromal and immune scores and tumor purity, defined as the quantitative proportions of immune and stromal components and malignant cells in tumor samples in different groups, were calculated using the estimation of stromal and immune cells in malignant tumor tissues using expression data (ESTIMATE) algorithm. The responses of patients with PTC to immune checkpoint blockade (ICB) therapy were predicted using the immune cell abundance identifier (ImmuCellAI) algorithm. The CIBERSORT algorithm results indicated that the infiltration levels of naive B cells, CD4 memory activated T_cells, regulatory T_cells (Tregs), M0 macrophages, resting dendritic cells, activated . . .

     

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