HIGHLIGHTS
- who: Keke Wu from the Su00e3o Paulo State University, Brazil have published the research: Nicotinamide mononucleotide attenuates HIF-1u03b1 activation and fibrosis in hypoxic adipose tissue via NAD+/SIRT1 axis, in the Journal: (JOURNAL)
- what: The study showed that NMN inhibited HIF-1a activation-induced adipose_tissue fibrosis and inflammation, while the underlying mechanism may be associated with the NAD+ repletion and the regulation of SIRT1 .
- how: Antibodies against the following proteins were obtained from Abcam TGF-b1 (ab92486) SIRT1 (ab110304) adiponectin (APN ab5694) and NAMPT(ab236874). Consistently whether in_vivo or in_vitro the results . . .
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