Investigating the role of sterol regulatory-element binding proteins (srebps) in age- related macular degeneration anjali sivamohan , ting wang and padmanabhan pattabiraman indiana university school of medicine; indiana university school of medicine, department of medical neuroscience; indiana university school of medicine, department of ophthalmology background/objective: srebps are transcription factors involved in lipid biogenesis and are known to play a role in angiogenesis. vascular endothelial growth factor (vegf) also promotes angiogenesis, with vegf inhibitors as the predominant treatment for age-related macular degeneration (amd). amd is the leading cause of permanent vision loss in the elderly population and is characterized by choroidal neovascularization (cnv). we hypothesize that vegf can activate srebps in a scap-dependent manner
who: anjali sivamohan from the Investigating the Role of Sterol Regulatory-Element Binding Proteins (SREBPs) in AgeRelated Macular Degeneration Anjali Sivamohan1, Ting Wang, and Padmanabhan Pattabiraman2, , Indiana University School of Medicine have published the paper: Investigating the Role of Sterol Regulatory-Element Binding Proteins (SREBPs) in Age- Related Macular Degeneration Anjali Sivamohan , Ting Wang and Padmanabhan Pattabiraman Indiana University School of Medicine; Indiana University School of Medicine, Department of Medical Neuroscience; Indiana University School of Medicine, Department of Ophthalmology Background/Objective: SREBPs are transcription factors involved in lipid biogenesis and are known to play a role in . . .
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