Rational enzyme design for enabling biocatalytic baldwin cyclization and asymmetric synthesis of chiral heterocycles

HIGHLIGHTS

  • who: Jun-Kuan Li from the Department of Chemistry, Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin, China Tianjin Institute of have published the research: Rational enzyme design for enabling biocatalytic Baldwin cyclization and asymmetric synthesis of chiral heterocycles, in the Journal: (JOURNAL) of 30/04/2022
  • how: The X-ray structures of variants solved in this study (PDB IDs 7VWD 7VX2 and 7VWM) were used as templates.

SUMMARY

    Analytical thin layer chromatography (TLC) was performed on 0.20 mm silica gel plates, while silica gel (200 . . .

     

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