HIGHLIGHTS
SUMMARY
The interaction of complementary metal-oxidesemiconductor (CMOS) electronics with biological entities, represents today a challenging multiphysics and multiscale case study in the field of neuroscience, given the different nature, scales, and physical properties of the system components. Multiscale-multiphysics finite-element modeling (FEM) and simulation platforms, perfectly serve the aim of estimating the neuron/electrode interaction in well defined physical conditions. The HH`s gating variables are computed solving a set of ordinary differential equations (ODE) at each membrane mesh point (Eq 6); consequently, the corresponding currents of the ionic channels are updated as . . .
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