One‐pot chemoenzymatic synthesis of microviridin analogs containing functional tags

HIGHLIGHTS

  • who: Tags and collaborators from the (UNIVERSITY) have published the paper: Oneu2010Pot Chemoenzymatic Synthesis of Microviridin Analogs Containing Functional Tags, in the Journal: (JOURNAL)
  • what: This experiment provides a proof of concept for the utility of microviridin chemical probes and highlights their potential even for derivatives whose activity might be compromised by introduced features. stitutively activated ATP-grasp ligases led to the synthesis of a series of N-terminally modified microviridin J and microviridin B derivatives, which alternatively would be hard to synthesize chemically from microviridin progenitors.
  • how: The work thus provides a . . .

     

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