Spyswitch enables ph- or heat-responsive capture and release for plug-and-display nanoassembly

HIGHLIGHTS

• who: Susan K. Vester from the University of have published the Article: SpySwitch enables pH- or heat-responsive capture and release for plug-and-display nanoassembly, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors aimed to establish a pH-switchable SpyCatcher003-based purification system that allows capture of SpyTagged proteins at 2 neutral pH, before eluting under weakly acidic conditions (Fig 1a). The features the authors show here are consistent with potential use of SpySwitch as a generic approach to purify candidate vaccine antigens, where the SpyTag will enable vaccine nanoassembly.
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