HIGHLIGHTS
SUMMARY
TP53 is a critical tumor suppressor gene located on chromosome 17p13.1 that encodes the p53 protein, which, in response to cellular stress, including deoxyribonucleic_acid (DNA) damage, increases in level and ultimately induces the transcription of the genes responsible for DNA damage repair and cell cycle arrest/apoptosis, among others. Among patients with a new diagnosis of acute myeloid leukemia (AML), at least 10% will have disease-harboring mutations in TP53 (TP53m-AML) but up to 30% in certain 2 of 19 subpopulations such as those with secondary AML, therapy-related AML (t-AML . . .
If you want to have access to all the content you need to log in!
Thanks :)
If you don't have an account, you can create one here.