Widespread emergence of ompk36 loop 3 insertions among multidrug-resistant clones of klebsiella pneumoniae

HIGHLIGHTS

  • who: Sophia David and colleagues from the Discovery, University of Oxford, Oxford, United Kingdom, MRC Centre for Molecular Bacteriology and have published the research work: Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae, in the Journal: (JOURNAL) of July/11,/2022
  • what: The authors show that in the absence of antibiotics KP mutants harbouring these L3 insertions exhibit both an in vitro and in vivo competitive disadvantage relative to the isogenic parental strain expressing wild type OmpK36. The authors propose that this explains the reversion of GD and TD . . .

     

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