Cellular abundance of sodium phosphate cotransporter slc20a1/pit1 and phosphate uptake are controlled post-transcriptionally by escrt

HIGHLIGHTS

  • who: Christoph Zechner from the Christoph Zechner1, , *, WMike Henne4, Adwait A. Sathe5, Chao Xing5, , Genaro Hernandez3, Shengyi Sun3, and Mi Cheong Cheong, From the Division of Endocrinology, Department of Internal Medicine have published the paper: Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT, in the Journal: (JOURNAL)
  • what: The authors show that SLC20A1 colocalizes with ESCRT and that ESCRT deficiency increases SLC20A1 protein and phosphate uptake into cells. Using a global CRISPR-based screening approach, the authors show that the ESCRT pathway tonically controls the cellular . . .

     

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