Mycn amplification, along with wild-type rb1 expression, enhances cdk4/6 inhibitors’ efficacy in neuroblastoma cells

HIGHLIGHTS

• who: Piergiuseppe De Rosa et al. from the Department of Pharmacy and Biotechnology, University of Bologna, Via Selmi, Bologna, Italy have published the research work: MYCN Amplification, along with Wild-Type RB1 Expression, Enhances CDK4/6 Inhibitorsu2019 Efficacy in Neuroblastoma Cells, in the Journal: (JOURNAL)
• what: The authors show that high of E2F3 and correlate with poor prognosis in NB despite the mRNA levels. The authors demonstrate through luciferase reporter assays that bypasses function by incrementing E2F3-responsive promoter activity. The authors aimed to provide additional information about the cell pathway driving the sensitivity 3 . . .
  

   

  

  If you want to have access to all the content you need to log in!

  Thanks :)

  Username or Email

  Password

  Remember me

  Lost your password?

  If you don't have an account, you can create one here.