Aspirin prevents estrogen deficiency-induced bone loss by inhibiting osteoclastogenesis and promoting osteogenesis

HIGHLIGHTS

• who: Yongyun Chang from the Animal experiments were conducted with permission from the Animal Care and Experimentation Ethics Committee of Shanghai Ninth People`s Hospital, Shanghai Jiao Tong University School of MedicineTwenty-four female Sprague-Dawley rats aged , weeks were randomly divided into four groups (n=6): (1) sham, (2) OVX, (3) OVX + low-dose aspirin (, mg/kg/day), and (4) OVX + high-dose aspirin (, mg/kg/day). Bilateral ovariectomy was performed to induce osteoporosis in the OVX, OVX + low-dose aspirin, and OVX + high-dose aspirin groups. A sham procedure without ovarian resection was performed in . . .
  

   

  

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