HIGHLIGHTS
- who: Julia M. Reber from the University of Konstanz, Constance, Germany have published the article: PARP1 and XRCC1 exhibit a reciprocal relationship in genotoxic stress response, in the Journal: (JOURNAL)
- what: The authors further analyzed the complex interplay between PARP1 and XRCC1 during genotoxic stress responses. Taken together, the authors propose that the cytotoxic effects of CPT, especially on XRCC1 KO cells, are at least partly caused by PARP1-dependent u00adNAD+ exhaustion, which is absent in the PARP1/XRCC1 DKO cell line and which can be prevented by pharmacological PARP inhibition. The fact that the . . .
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